The National Football League (NFL) is the largest and most prestigious professional American football league, consisting of thirty-two teams from American cities and regions. The league's teams are divided into two conferences: the American Football Conference (AFC) and the National Football Conference (NFC). Each conference is then further divided into four divisions consisting of four teams each, labeled North, South, East, and West.

During the league's regular season, each team plays sixteen games over a seventeen-week period, generally from September to December. At the end of each regular season, six teams from each conference play in the NFL playoffs, a twelve-team single-elimination tournament that culminates with the NFL championship, the Super Bowl.

This game is held at a pre-selected site which is usually a city that hosts an NFL team. One week later, selected all-star players from both the AFC and NFC meet in the Pro Bowl, currently held in Honolulu, Hawaii. The NFL was formed in 1920 as the American Professional Football Association and adopted the name National Football League in 1922.

The NFL is one of the major professional sports leagues of North America, a group also including Major League Baseball, the National Basketball Association, Major League Soccer and the National Hockey League. The NFL is one of the most popular sports leagues in the United States, and has the highest per-game attendance of any domestic professional sports league in the world, drawing over 67,000 spectators per game for its most recently completed season in 2006.